News
2025
May
- Congratulations to Zijian on the publication of the paper “An Explainable Multimodal Artificial Intelligence Model Integrating Histopathological Microenvironment and EHR Phenotypes for Germline Genetic Testing in Breast Cancer” in Advanced Science.
- Congratulations to Ke on the publication of the paper “Spatiotemporal single-cell analysis elucidates the cellular and molecular dynamics of human cornea aging” in Genome Medicine.
- Congratulations to Yibo on the publication of the paper “Biopsy image-based deep learning for predicting pathologic response to neoadjuvant chemotherapy in patients with NSCLC” in npj Precision Oncology.
April
- Congratulations to Yichun and Jiaqi on the publication of the paper “PCMR: a comprehensive precancerous molecular resource” in Scientific Data.
March
- Congratulations to Zicheng and Siqi on the publication of the paper “Proteogenomic characterization of high-grade lung neuroendocrine carcinoma deciphers molecular diversity and potential biomarkers of different histological subtypes in Chinese population” in Research.
- Congratulations to Yichun on the publication of the paper “Transcriptomic profiling of blood platelets identifies a diagnostic signature for pancreatic cancer” in British Journal of Cancer.
February
- Congratulations to Congcong on the publication of the paper “Comprehensive transcriptomic profiling reveals molecular characteristics and biomarkers associated with risk stratification in papillary thyroid carcinoma” in Journal of Pathology Clinical Research.
- Congratulations to Jie on the publication of the paper “Single Cell Inference of Cancer Drug Response Using Pathway-Based Transformer Network” in Small Methods.
January
- Congratulations! Ye contributed a paper about “Pan-cancer characterization of m6A-mediated regulation of T cell exhaustion dynamics and clinical relevancies in human cancers” on Molecular Therapy: Nucleic Acids.
2024
December
- Congratulations! Dongxue contributed a paper about “Leveraging pharmacovigilance data to predict population-scale toxicity profiles of checkpoint inhibitor immunotherapy” on Nature Computational Science.
November
- Ke’s work about “Single-cell and bulk transcriptome analysis reveals tumor cell heterogeneity and underlying molecular program in uveal melanoma” was published on Journal of Translational Medicine. Congratulations!
September
- Congratulations! Meng’s cooperation work about Deciphering the role of LGALS2: insights into tertiary lymphoid structure-associated dendritic cell activation and immunotherapeutic potential in breast cancer patients was published on Molecular Cancer!
- Meng was certificated as one of World’s Top 2% Scientists by Stanford University/Elsevier. Congratulations to Meng!
August
- Zicheng’s work about “Causal relationships between retinal diseases and psychiatric disorders have implications for precision psychiatry” was accepted by Molecular Neurobiology. Congratulations!
July
- Congratulations! Xinrui’s paper about The transcriptional landscape and clinico-biological characterization of human endogenous retroviruses (HERVs) in esophageal squamous cell carcinoma was accepted by International Journal of Cancer!
- Congratulations to Lili’s paper about Integrated immuno-transcriptomic analysis of ovarian cancer identifies a four-chemokine-dominated subtype with antitumor immune-active phenotype and favorable prognosis accepted by British Journal of Cancer!
June
- Congratulations! Zijian’s paper about Automated early detection of acute retinal necrosis from ultra-widefield color fundus photography using deep learning was accepted by Eye and Vision!
- Congratulations! Zicheng’s paper about Spatial Transcriptome-Wide Profiling of Small Cell Lung Cancer Reveals Intra-Tumoral Molecular and Subtype Heterogeneity was published on Adv Sci!
May
- Congratulations to Yixin’s paper about Systemic whole transcriptome analysis identified underlying molecular characteristics and regulatory networks implicated in the retina following optic nerve injury published on Experimental Eye Research!
- Yixin, Hongyan, Ye, Desen, Ronghua, Yaxuan, Ke, Dongxue, Zijian and Yibo successfully defended their MS theses. Congratulations!
March
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Meng has been selected as one of the 2023 Most Cited Chinese Researchers (released by Elsevier). Congratulations to Meng!
- Congratulations to Hongyan’s paper about Inference of developmental hierarchy and functional states of exhausted T cells from epigenetic profiles with deep learning accepted by Journal of Chemical Information and Modeling!
- Congratulations! Modi’s paper about Genetic insights into association and causality between blood metabolites and Alzheimer’s disease was accepted by Journal of Alzheimer’s Disease!
February
- Congratulations! Yaxuan and Ronghua’s paper about Effect of the gut microbiome in glaucoma risk from the causal perspective was published on BMJ Open Ophthalmol!
January
- Congratulations! Ronghua and Yaxuan’s paper about The causal effect of oxidative stress on the risk of glaucoma was accepted by Heliyon!
- Congratulations! Zijian, Yibo, Jie and Meng’s paper about Prediction of prognosis and treatment response in ovarian cancer patients from histopathology images using graph deep learning: a multicenter retrospective study was accepted by European Journal of Cancer!
- Congratulations! Yibo, Zijian and Meng’s paper about Histopathology images-based deep learning prediction of prognosis and therapeutic response in small cell lung cancer was accepted by npj Digital Medicine!
2023
December
- Congratulations! Hongyan and Meng’s paper about Consensus clustering with missing labels (ccml): a consensus clustering tool for multi-omics integrative prediction in cohorts with unequal sample coverage was accepted by Briefings in Bioinformatics!
November
- Congratulations to Meng about collaborating paper of Single-Cell Landscape Reveals the Epithelial Cell-Centric Proinflammatory Immune Microenvironment in Dry Eye Development published on Mucosal Immunology!
October
- Congratulations! Ke Li’s paper about Sing-cell dissection of the multicellular ecosystem and molecular features underlying microvascular invasion in hepatocellular carcinoma was accepted by HEPATOLOGY!
- Congratulations! Ke Xu’s paper about Automatic detection and differential diagnosis of age-related macular degeneration from color fundus photographs using deep learning with hierarchical vision transformer was published on Computers in Biology and Medicine!
- Congratulations! Ke Li’s paper about Single-cell characterization of macrophages in uveal melanoma uncovers transcriptionally heterogeneous subsets conferring poor prognosis and aggressive behavior was published on Experimental & Molecular Medicine!
August
- Congratulations to Zicheng and Meng contributing a paper about DNA damage repair profiling of esophageal squamous cell carcinoma uncovers clinically relevant molecular subtypes with distinct prognoses and therapeutic vulnerabilities on eBioMedicine!
- Congratulations to Yibo, Congcong, Meng and Jie contributing a paper about Multi-omics Deep-learning Prediction of Homologous Recombination Deficiency-like Phenotype Improved Risk Stratification and Guided Therapeutic Decisions in Gynecological Cancers on IEEE J Biomed Health Inform!
- Meng Zhou starts his lab in Computational Precision Health (ZSlab@CPH) at Wenzhou Medical University!
July
- Congratulations to Lu, Meng and Jie contributing a paper about Noninvasive early differential diagnosis and progression monitoring of ovarian cancer using the copy number alterations of plasma cell-free DNA on Transl Res!
- Congratulations to Zhenhui, Chenghao and Jianzhong contributing a review about Liquid biopsies for cancer: From bench to clinic on MedComm!
- Congratulations! Zicheng, Hongyan, Jie and Meng contributed a paper about Deep learning identifies a T-cell exhaustion-dependent transcriptional signature for predicting clinical outcomes and response to immune checkpoint blockade on Oncogenesis.
- Congratulations! Zicheng and Meng contributed a paper about Multi-dimensional characterization of immunological profiles in small cell lung cancer uncovers clinically relevant immune subtypes with distinct prognoses and therapeutic vulnerabilities on Pharmacological Research.
June
- Congratulations! Meng, Siqi and Jianzhong contributed a paper about The transcriptional landscape and diagnostic potential of long non-coding RNAs in esophageal squamous cell carcinoma on Nature Communications.
- Congratulations to Zijian, Jie and Meng for publishing paper about DeepDrRVO: A GAN-auxiliary two-step masked transformer framework benefits early recognition and differential diagnosis of retinal vascular occlusion from color fundus photographs on Computers in Biology and Medicine!
- Congratulations! Shilai, Yinghao, Jianzhong contributed a paper about Association of mitochondrial DNA variation with high myopia in a Han Chinese population on Molecular Genetics and Genomics.
May
- Congratulations! Jianzhong, Jian, Shilai contributed a paper about Sequencing of 19,219 exomes identifies a low-frequency variant in FKBP5 promoter predisposing to high myopia in a Han Chinese population on Cell Reports.
- Xinyu, Lijun and Jianzhong contributed an article about Partial erosion on under-methylated regions and chromatin reprogramming contribute to oncogene activation in IDH mutant gliomas on Epigenetics & Chromatin. Congratulations!
April
- Congratulations! Jianzhong's collaboration paper with Prof. Li about scRNA-seq reveals new subtypes of lens superficial tissue in humans was published on Cell Proliferation.
March
- Congratulations! Xinrui and Zhengbo's review about the roles of non-coding RNAs in eye development and diseases was accepted on WIREs RNA.
February
- Congratulations! Congcong's collaboration paper with Prof. Lin about Metabolite Biomarkers for Differential Detection of Macular Edema was accepted on eye and vision.
2022
November
- Congratulations! Dandan and Xinyu's collaboration paper with Prof. Zhang about Mutant NPM1 hijacks transcriptional hub to maintain pathogenic gene programs in acute myeloid leukemia was accepted on Cancer Discovery.
October
- Congratulations! Congcong's collaboration paper with Prof. Ma and Prof. Zheng about clinical role and molecular mechanisms of the SLC12 family in uveal melanoma was accepted on Laboratory Investigation.
July
- Congratulations! Siqi's collaboration paper with Prof. Xu about Early non-invasive diagnosis of pre-eclampsia was accepted on BMC Medicine.
- Congratulations! Zicheng and Lu's paper about Pan-cancer landscape of T cell exhaustion heterogeneity was accepted on eBioMedicine.
June
- Zhengbo, Yukuan, Zicheng, Congcong, Fangjie, Ji and Fukun graduated! Congratulations and best wishes!
- Congratulations to Zhengbo, Jian, and Fukun, their paper about genetic relationships and pleiotropic mechanisms of five ocular diseases was accepted on eBioMedicine.
- Congratulations! Jingting's paper about Multi-omics deep learning model for rationalized hypoxia-targeted therapy in UVM was accepted on Computational and Structural Biotechnology Journal.
April
- Congratulations! Congcong 's paper about Computational inference of susceptibility genes in UVM was accepted on npj Systems Biology and Applications.
- Congratulations! Congcong and Ke Li's paper about A macrophage activation paradigm of ovarian cancer was accepted on Journal of advanced research.
- Congratulations! Zicheng's collaboration paper with Prof. Wang about Adjuvant Chemotherapy for Gastric Cancer was accepted on Journal of Gastric Cancer！
February
- Congratulations! Yukuan and Hengqiang's collaboration paper with Prof. Wu about Identifying Hereditary Breast Cancer through Deep Learning was accepted on Genome Medicine！
January
- Congratulations! Xinyu's collaboration paper with Prof. Lin about DNA methylation diagnostic and prognostic markers for esophageal squamous-cell carcinoma was accepted on Signal Transduction and Targeted Therapy.
- Yunlong, Fei, Chunyu, Jingjing and Yukuan contributed a paper about integrating scRNA-seq with GWAS to discover genetics-influenced CD16+ monocytes and memory CD8+T cells involved in severe COVID-19 on Genome Medicine. Congratulations!
- Congratulations! Lu's collaboration paper with Prof. Shen about Transcriptional landscape of circulating platelets from patients with COVID-19 was accepted on Cell & Bioscience.
2021
December
- Merry Christmas and Happy New Year 2022!
- Congratulations! Ke, Congcong and Chenghao's paper about Computational elucidation of spatial gene expression variation from spatially resolved transcriptomics data was accepted on Molecular Therapy - Nucleic Acids.
November
- Congratulations! Jie, Congcong's collaboration paper with Prof. Hao about Immuno-genomic characterization of high-grade serous ovarian cancer was accepted on British Journal of Cancer.
October
- Meng, Ping, Congcong, Jianzhong and Jie contributed a paper about Cell-free DNA 5-hydroxymethylcytosine of lncRNA as biomark for cancer on Clinical Epigenetics. Congratulations!
- Congratulations! Prof. Zhou's collaboration paper with Prof. Åsa Wheelock about Multiomics integration-based molecular characteristics of COVID-19 was accepted on Briefings in Bioinformatics
- Congratulations! Zicheng's collaboration paper about clinical five-risk factor panel for acute anterior uveitis recurrence was accepted on Translational Vision Science & Technology (TVST).
- Congratulations! Siqi and Ke's paper about Deep learning in single-cell RNA-sequencing data analysis was accepted on Briefings in Bioinformatics.
- Congratulations! Ping and Congcong's paper about Cell-free 5hmC profiles of lncRNAs in cancer detection and progression monitoring was accepted on Clinical Epigenetics.
September
- Congratulations. Chunyu and Jianzhong's collaboration paper about genetic source tracking of human urinary exosomes was accepted on PNAS.
- Congratulations to Wei and Jianzhong for paper about non-classically secreted proteins in Gram-positive bacteria accepted by Nucleic Acids Research.
- Congratulations! Yunlong, Jian and Jianzhong contributed a paper about whole city-million scale children and adolescents myopia survey (CAMS) in Wenzhou on Eye and Vision.
July
- Congratulations! Jian, Qi, Dandan and Jianzhong's work about loss of H3K27me3 in ESCC activate transcription was accepted on npj Genomic Medicine.
- Congratulations to Jianzhong for collaborative publication about de novo protein structure prediction in Bioinformatics.
June
- Congratulations! Dandan's collaboration paper with Prof. Qiao about ESCC oncogenic enhancers was accepted in Nature Communications.
- Congratulations! Zicheng's collaboration paper with Prof. Zheng about Crosstalk between epithelial-mesenchymal transition and immune evasion was accepted in npj Precision Oncology.
- Jian, Fukun, Dandan and Jiangzhong contributed EyeDiseases database on NAR Genomics and Bioinformatics. Cheers!
May
- Congratulations! Zicheng's collaboration paper with Dr. Wang about Adjuvant Chemotherapy Efficacy Comparison of SOX and XELOX in Stage II-III GC Patients was published in Frontiers in Oncology.
- Congratulations! Siqi's collaboration paper with CHCAMS about Circulating exo-miRNA inhibits breast cancer LNM was accepted in Molecular Oncology.
- Congratulations! Zicheng's paper about Pan-cancer lncRNA modifiers of immune microenvironment was accepted in npj Genomic Medicine.
- Dandan, Siqi, Qi, Yaru and Ping successfully defended their MS theses. Congratulations!
- Yunlong, Yukuan and Jianzhong's paper about genomic susceptibility locus of COVID-19 was published on Human Molecular Genetics. Congratulations!
April
- Congratulations! Yunlong, jian, Yaru and Jianzhong's paper titled “COVID-19 quarantine reveals behavioral changes effect on myopia progression” was accepted on Ophthalmology.\
- Congratulations to Jian on his new baby girl. Cheers!
February
- Hengqiang, Yukuan and Jianzhong contributed an article in Molecular Cancer. Congratulations!
- Happy spring festival! Bless for 2021!
January
- Congratulations to Yuanjian and Jianzhong for contributing a collaboration paper on The American Journal of Human Genetics. Cheers!
- Congratulations! Jianzhong's collaboration paper with Li Lab is online at Nature Communications.
- Siqi's collaboration paper about an EV-derived GI-associated miRNA signature in breast cancer is online at Journal of Nanobiotechnology! Congratulations!
- Yunlong had a baby girl. Congratulations!
- Congratulations! Ping, Siqi and Dandan's work about DNA methylation signature in uveal melanoma was accepted in Briefings in Bioinformatics.
- Congratulations! Siqi’s collaboration paper about an EV-derived GI-associated miRNA signature in breast cancer with Chen Lab and Wu Lab was accepted in Journal of Nanobiotechnology.
2020
December
- Merry Christmas & Happy New Year!
November
- Congratulations! Yan, Fulong and Yaru's collaboration paper about single cell RNA-seq reveals cancerous origin with Jin Lab was accepted in PNAS.
October
- Congratulations! Jianzhong Collaboration's paper about Discovery of Oncogenes and Tumor Suppressor Genes was published in Science Advance.
- Su Lab had a wonderful day in Dongtou district.
- Congratulations！ Yaru and Yunlong's work for pathway activity transformation of single-cell RNA-seq data was accepted in Computational and Structural Biotechnology Journal.
September
- Congratulations! Jian Yuan and Dan Dan's work about cricial mitochondrial genes in cornea affected by COVID-19 was accepted in IOVS.
- Congratulations! Jianzhong Collaboration's paper about Discovery of Oncogenes and Tumor Suppressor Genes was accepted in Science Advance.
July
- Congratulations! Congcong's paper about Computational methods and applications of disease lncRNAs was published to Molecular Therapy-Nucleic Acids.
- Congratulations! Jianzhong’s collaboration paper with Li Lab was accepted in Nature Communications.
June
- Congratulations! Yan and Yaru’s paper of single-cell pathways annotation tool was accepted in Bioinformatics.
March
- Congratulations! Xinyu’s collaboration paper with Zhang Lab was published in Blood.
- Zicheng and Hengqiang’s collaboration paper with Jin Lab was published to Molecular Therapy-Nucleic Acids.
February
- Congratulations! Yan, Zhengbo and Fangjie’s ncRNAomics knowledgebase paper was accepted in Front Cell Dev Biol.
- Congratulations! Jie, Zicheng and Siqi’s tumor immune infiltration-associated lncRNAs in NSCLC paper was published in Journal for ImmunoTherapy of Cancer.
January
- Congratulations! Long, Kai and Quan’s Cell-free epigenome atlas in human diseases paper was published in Nucleic Acids Research
- Happy New Year 2020！
- Congratulations! Meng, Zicheng and Siqi’s lncRNA signature of tumor-infiltrating B lymphocytes paper was accepted in Briefings in Bioinformatics
- Congratulations! Zicheng’s computational advances in decoding immune contexture paper was accepted in Briefings in Bioinformatics
- Congratulations! Hengqiang’s patient-level framework for precision medicine paper was accepted in Briefings in Bioinformatics
2019
November
- Congratulations! Jian’s molecular signatures in devastating endophthalmitis paper was accepted in mSystems
August
- Congratulations! Yan and Long’s circRNA in Alzheimer’s disease paper was accepted in Frontiers in Bioengineering and Biotechnology
- Congratulations! Siqi’s lncRNA signatures of genome instability paper was accepted in Briefings in Bioinformatics.
July
- Congratulations! Jie and Siqi’s Individualized gene signature in chemotherapy paper was accepted in Cell Death & Disease.
June
- The lab welcomes new graduates: Zicheng Zhang, Ji Zhang, Yukuan Huang, Congcong Yan and Fukun Cheng
May
- Celebrating the Success of International Forum of Genetics and Epigenetics in Precision Medicine, IFGE2019, and the Unveiling of the Biomedical Big Data Institute.
- Congratulations! Jie, Qiang and Ting’s function-derived personalized multi-gene signature of outcome in colorectal cancer paper was accepted in JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
2018
December
- Merry Christmas！
November
- Congratulations! Dr Su’s grant application of outstanding youth has been funded by Zhejiang natural fund committee.
August
- Congratulations! Dr. Zhou’s grant application has been funded by NSFC.
- Congratulations! Dr. Su’s grant application has been funded by NSFC.
- Congratulations! Jianzhong’s Pan-Cancer DNA Hypermethylation and homeobox oncogenes paper was published in Genome Biology
July
- Congratulations! Jianzhong’s Pan-Cancer DNA Hypermethylation and homeobox oncogenes paper was accepted in Genome Biology
June
- Congratulations! Meng and Hu’s lncRNA signature in colon cancer recurrence paper was accepted in Molecular Therapy-Nucleic Acids.
May
- The lab welcomes new graduates: Dandan Fan, Siqi Bao, Qi Jiang, Yaru Zhang and Ping Hou
- Our team at the 2018 Forum for Genetics and Epigenetics of Skeletal Associated Disorders meeting, Beijing, China
- Congratulations! Meng and Qiang’s lncRNA and Alzheimer’s disease paper was accepted and is online in Briefings in Bioinformatics
April
- Professor Su was invited to the The International Consortium for Spinal Genetics, Development and Disease Conference